Cialis vs Viagra – features and comparative analysis of medications.

Cialis, as well as its competitor Viagra, is a highly popular medicament used by millions of men in order to cure problems with penile erection. The first remedy is produced by Eli Lilly corporation; the second one is manufactured by Pfizer in the form of a blue tablet, which looks like a diamond. Differences between medicines consist of not only tablet form and color. The main agent of the yellow pill is Tadalafil, while the blue pill’s active agent is called sildenafil. These substances differ from one another by absorption rate, duration of action, interaction with food etc.

Viagra vs Cialis – absorption rate

Researchers examined the dependence of the efficiency of these two anti-ED remedies on the meal. The average efficiency of Viagra was higher (85%) when it was taken on an empty stomach than after a meal (68%). Cialis showed better results when used after a meal– 84% and 81% respectively. However, bad effects of both medicaments in the fasting state were approximately 2 times higher than after ingestion of food (20% & 9% when taking the blue pill and 18% & 10% when taking Cialis). The speed of onset of action of Viagra was significantly reduced (from 15 minutes on an empty stomach to 90 minutes after a meal), in the case of Cialis this indicator was increased from 18 to 30 min. So, Cialis can be advised to be taken after meals with no loss of efficiency in order to reduce the severity of bad effects, but it is impossible to say the same about Viagra. This fact is explained by the pharmacodynamic characteristics of these medicaments.

Cialis vs Viagra – how long do they act?

The positive effect of Viagra is maintained for 6 hours and virtually disappears in 24 hours after ingestion. The efficiency of its competitor is maintained at an approximately similar level during the 36-hour period. It is one of the main benefits of Cialis as the medicament provides a possibility to have spontaneous sex for a long time. Due to this benefit, patients don’t have any psychological dependence connected with the need to take a pill before sex.

Other Cialis alternatives

There are other medicaments of PDE5i family, such as Levitra, Stendra, and Zydena. Levitra containing vardenafil as the main agent was developed by Bayer Pharmaceuticals in cooperation with Schering-Plough and GlaxoSmithKline. This medicament is absorbed rapidly (in 15-30 minutes) and is effective for 4-5 hours.
Stendra (avanafil) was developed by VIVUS Inc. and was approved by the US Food & Drug Administration in 2012. It contains a high dosage of the key active agent (from 50 to 200 mg).

Zydena (Sildenafil) is produced by Korean firm called Dong-A Pharmaceutical Co. This medicament has a long duration of effect (from 11 to 13 hours). Typical dosages are 100 & 200 milligrams. In the USA, it isn’t approved by state bodies (FDA).
In case of ineffectiveness of inhibitors of PDE5, intracavernous injection may be used. A variety of drugs is used for such injections. Today, doctors usually prescribe papaverine, phentolamine and alprostadil, alone or in various combinations. Intracavernous injections are effective in approximately 80% of patients. The main thing in this method of anti-ED therapy is that it allows a male person suffering from ED to have a full erection at the right time. Penile erection emerges after injection regardless of a sexual partner’s sex appeal.