What does Cialis do: the mechanism of action and duration of effect.

Cialis is a highly popular remedy used for curing problems with male potency. It is produced by pharmaceutical giant Eli Lilly and belongs to the family of medicaments inhibiting PDE5. Below you’ll find some interesting information about principles of action of this medicament, its efficiency and price in the USA.

What does Cialis do?

Cialis has a very delicate effect on the reproductive system, selectively inhibiting the activity of the enzyme PDE-5, which is responsible for the breakdown of energy compounds in the corpora cavernosa of the penile organ. The mechanism of penile erection occurrence is as follows: after sex stimulation, NO molecules are released in the tissues of the penis. It leads to the relaxation of the muscles, which stop blood flow on its way to the male organ.

How does Cialis work?

The medicament does not directly affect the relaxation of the muscle tissue, this effect occurs due to the inhibition of the PDE5 enzyme. As a result, nitrogen oxide provides a significant relaxing effect. Studies have shown that Viagra has highly selective activity and acts primarily against PDE5. For other types of phosphodiesterase (there are many such types), its activity is much lower, and this is a huge benefit. Otherwise, the medicament would be classified as a nerve poison!
It has been established experimentally that the PDE5 inhibitors affect the enzyme PDE-5 by approximately 80 times stronger than the first type of PDE and by more than 1000 times stronger than PDE3 and PDE4.
Therefore, the occurrence of bad effects on other body systems is minimal, if a male person takes recommended dosage as prescribed by a qualified healthcare professional.

How long does it take for Cialis to work?

In some male persons, the remedy takes effect within 16 min. For most patients, this time is around 30 minutes. But remember, needed effect does not occur without sex stimulation. Fatty or any other food has no effect on the rate of absorption of the main agent of the medicament into the bloodstream. Therefore, this anti-ED remedy can be recommended to be taken after meals without any loss of efficiency.

How long does Cialis last?

The effectiveness of the remedy is maintained at approximately the same level for thirty-six hours. It is one of the main advantages of Cialis, not because a patient needs a prolonged erection, but because the medicament provides a spontaneous sex activity for a long time, while the direct psychological connection between sex activity and a tablet doesn’t exist. Due to this feature, the medicament was called a “weekend pill” by patients and their partners. A male person can take the yellow tablet on Friday evening and the active agent of the medicament will act up to Monday morning.

How much does Cialis cost in the USA?

The average price of one Cialis pill in the USA varies from 40 to 41 dollars. According to the data posted on accessrx.com, as for 2015, Las Vegas average price for 1 tablet is $40.91, the average price per pill in Austin city is $41.07. In 2017, the generics of Cialis will officially come to US market (as a Cialis patent will expire in 2017), therefore, the price of such medicaments will be significantly lower.